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Volume 11, Issue 2 (6-2014)
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Esmailidehaj M, Fatehi H, Keshtavar M, Hejazian S H, SH Bajoovand S, Alihosaini J. Comparison of the effects of carvacrol and lidocaine on aconitine-induced arrhythmias in rats. Mod Care J 2014; 11 (2) :136-144
URL: http://mcj.bums.ac.ir/article-1-454-en.html
URL: http://mcj.bums.ac.ir/article-1-454-en.html
Mansour Esmailidehaj *1 
, Hamidreza Fatehi2 , Mohammad Keshtavar3 , Seyed Hasan Hejazian4 , Shirin SH Bajoovand5 , Jamileh Alihosaini5
, Hamidreza Fatehi2 , Mohammad Keshtavar3 , Seyed Hasan Hejazian4 , Shirin SH Bajoovand5 , Jamileh Alihosaini5
1- Mansour Esmailidehaj, Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email: med1354@ssu.ac.i
2- M.Sc. Student of Animal Physiology, Faculty of Basic Sciences, Islamic Azad University, Fars Sciences and Research Branch, Shiraz, Iran
3- M.Sc. Student of Animal Physiology, Faculty of Basic Sciences, Islamic Azad University, Arsenjan Branch, Arsenjan, Iran
4- Assistant Professor, Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5- M.Sc., Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- M.Sc. Student of Animal Physiology, Faculty of Basic Sciences, Islamic Azad University, Fars Sciences and Research Branch, Shiraz, Iran
3- M.Sc. Student of Animal Physiology, Faculty of Basic Sciences, Islamic Azad University, Arsenjan Branch, Arsenjan, Iran
4- Assistant Professor, Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5- M.Sc., Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (247 Views)
Background and AimPrevious studies have shown that carvacrol has hypotensive, bradycardic and calcium inhibitory effects. Since the opening of calcium channels have an important role in the incidence of arrhythmias , this study aimed to investigate whether carvacrol has anti-arrhythmic effects against aconitine-induced arrhythmia or not. Materials and MethodsIn this experimental study, seventy male Wistar rats were divided into seven groups of tenGroup 1 as the control Group Group 2 as the pretreatment with lidocaine (10 mg/kg) Group 3 and 4 as the pretreatment with carvacrol 10 and 50 µg/kg Group 5 as the treatment with lidocaine (10 mg/kg) and Group 6 and 7 as the treatment with carvacrol 50 µg/kg. Lidocaine and carvacrol were infused intravenously as pretreatment and treatment respectively before and after the infusion of aconitine (as an arrhythmic substance). Ventricular arrhythmia including the onset of arrhythmia, incidence percentage of ventricular tachycardia and fibrillation, and irreversible ventricular fibrillation and atrial fibrillation were monitored following the infusion of aconitine for 30 minutes. Data were analyzed in GraphPad Prism statistical software by one-way ANOVA, Tukey’s post hoc test, and Fisher’s exact test. ResultsData showed that the magnitude of ventricular arrhythmia including the onset of arrhythmia, incidence percentage of ventricular tachycardia and fibrillation, and irreversible ventricular fibrillation significantly reduced in pretreatment and treatment groups with lidocaine. It also reduced markedly in pretreatment and treatment groups with carvacrol 50 µg/kg, although not as much as in the lidocaine group. There was not any significant difference between carvacrol 10 µg/kg groups and control group both in pretreatment and treatment protocol. ConclusionThe findings of this study indicate that the maximum dose of carvacrol which did not have any significant effect on blood pressure reduced the magnitude of aconitine-induced arrhythmia. This may use prevention and alternative of cardiac arrhythmias
Article Types: Research Article |
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Received: 2026/01/25 | Accepted: 2026/01/26 | Published: 2026/01/26
Received: 2026/01/25 | Accepted: 2026/01/26 | Published: 2026/01/26
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