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Volume 13, Issue 3 (7-2016)
Mod Care J 2016, 13(3): 0-0 |
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Valavi M, Mezginejad F, Haghighi F, Hemmati M, Zarban A, Rabiei Gask E. Effectiveness of Aqueous and Alcoholic Extracts of Barberry, Jujube, and Saffron Against Oxidative Stress in Streptozotocin-Induced Diabetic Rats. Mod Care J 2016; 13 (3)
URL: http://mcj.bums.ac.ir/article-1-57-en.html
URL: http://mcj.bums.ac.ir/article-1-57-en.html
Maryam Valavi1 
, Fateme Mezginejad1 , Fatemeh Haghighi2 , Mina Hemmati *3 , Asghar Zarban4 , Elham Rabiei Gask2
, Fateme Mezginejad1 , Fatemeh Haghighi2 , Mina Hemmati *3 , Asghar Zarban4 , Elham Rabiei Gask2
1- Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
2- Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
3- Mina Hemmati, Ph.D, Associate Professor in Clinical Biochemistry Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Tel: +98-5632381541, Fax: +98-5632393004, E-mail: minahemmati@bums.ac.i
4- Biochemistry Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
2- Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
3- Mina Hemmati, Ph.D, Associate Professor in Clinical Biochemistry Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Tel: +98-5632381541, Fax: +98-5632393004, E-mail: minahemmati@bums.ac.i
4- Biochemistry Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Abstract: (9 Views)
Background: The use of herbal medicine has recently increased because of its effectiveness, limited side effects, and easy accessibility. In the present study, we investigated the antioxidant properties and diabetes treatment potential of 3 medicinal plants of barberry, saffron, and jujube. Methods: In the present study, 65 diabetic male Wistar rats were randomly divided into 13 groups. Groups 1 to 6 included diabetic rats that received hydroalcoholic extracts and groups 7 to 12 received aqueous extracts of the plants. The rates in Group 13 were diabetic controls, and 5 male Wistar rats were used as non-diabetic controls. Total antioxidant capacity, lipid peroxidation, radical scavenging activity, and fasting blood glucose were measured at the end of the 21st day of the treatment. Results: Hydroalcoholic and aqueous extracts of the plants decreased malondialdehyde, and in contrast, increased total antioxidant levels (P ≤ 0.05). Increased levels of insulin and decreased levels of FBG in all treated groups were observed, which were notable for hydroalcoholic extract of saffron. Conclusions: The antioxidant properties of the plants, especially saffron and jujube, lead to the regeneration of pancreatic islet and probably increase insulin release in these treatment groups; and, the plants exert their beneficial antidiabetic effects because of their antioxidant potential.
Article Types: Research Article |
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Received: 2026/01/10 | Accepted: 2016/07/15 | Published: 2016/07/15
Received: 2026/01/10 | Accepted: 2016/07/15 | Published: 2016/07/15
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