The Comparison of Antimicrobial Effect of New Herbal with Standard Toothpaste with Their Influence on Gingival Health Indexes: A Randomized Clinical Trial

Akbari, Narjes; Ahmadi, Hamid; Shafaie, Ebrahim; Rajabi, Omid; Sharifzadeh, Gholamreza; Tahergorabi, Zoya

doi:10.5812/modernc-131543

Volume 20, Issue 1 (1-2023) Mod Care J 2023, 20(1): 0-0 | Back to browse issues page

‎ 10.5812/modernc-131543

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Akbari N, Ahmadi H, Shafaie E, Rajabi O, Sharifzadeh G, Tahergorabi Z. The Comparison of Antimicrobial Effect of New Herbal with Standard Toothpaste with Their Influence on Gingival Health Indexes: A Randomized Clinical Trial. Mod Care J 2023; 20 (1)
URL: http://mcj.bums.ac.ir/article-1-253-en.html

The Comparison of Antimicrobial Effect of New Herbal with Standard Toothpaste with Their Influence on Gingival Health Indexes: A Randomized Clinical Trial

Narjes Akbari¹

, Hamid Ahmadi²

, Ebrahim Shafaie³

, Omid Rajabi⁴

, Gholamreza Sharifzadeh⁵

, Zoya Tahergorabi ^*⁶

1- Department of Oral & Maxillofacial Diseases, School of Dentistry, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
2- Student Research Committee, School of Medicine, Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
3- Department of Medical Microbiology, School of Medicine, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
4- Department of Drug Control, School of Pharmacy, Targeted Drug Delivery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5- Department of Epidemiology and Biostatistics, School of Health, Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
6- Medical Toxicology and Drug Abuse Research Center, Department of Physiology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran , z.tahergorabi@yahoo.com

Abstract: (10 Views)

Background: Dental caries, gingivitis, and periodontitis are considered the most common oral and dental health problems in different parts of the world. Objectives: The present study aimed to evaluate the antibacterial activity, plaque index, and gingival index determination of herbal toothpaste compared with standard toothpaste. Methods: The present study is a randomized clinical trial on 60 participants of 18 - 28 years and a minimum of 24 healthy teeth at Birjand Dental School that were randomly divided into two groups, herbal and standard toothpaste (n = 30 each group); only participants were blind. All subjects brushed their teeth for 3 minutes 2 times a day for seven months. The plaque index (PI) and gingival index (GI) for each participant also, saliva samples were taken from the subjects for Streptococcus mutans and Lactobacillus spp., colony count at the onset of the study, and 3, 5, and 7 months after toothpaste usage. Results: This study was conducted on 60 patients in two study groups. No significant statistical difference was observed between age and gender in the two studied groups. Our study showed that the mean number of S. mutans in the two groups was not significantly different (P > 0.05), but the mean number of Lactobacillus spp. in the group of herbal toothpaste at three months (P = 0.02) and seven months (P = 0.002) was significantly less than standard toothpaste. Also, the mean PI and the GI indices in the herbal toothpaste group after use for five months (P = 0.02) (P = 0.03) and seven months (P < 0.001) (P = 0.03), respectively, were significantly lower than standard toothpaste. Conclusions: Throughout the 7-month trial, herbal toothpaste showed higher antimicrobial activity against Lactobacillus spp. than standard toothpaste, effectively reducing dental plaque and gingivitis. Furthermore, no undesirable reactions to toothpaste were reported during the trial. Therefore, it was concluded that possibly novel herbal toothpaste could be an alternative for controlling dental plaque and gingivitis. Further studies are needed.

Keywords: Periodontal index, Herbal, Toothpaste, Lactobacillusspp, Streptococcus mutans

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Article Types: Research Article | Subject: General
Received: 2026/01/10 | Accepted: 2023/01/15 | Published: 2023/01/15