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Background and AimChronic stress can cause irritability and mood instability and it is an important factor in increasing anxiety and depression. Regarding the importance of decreasing stress, anxiety, and depression using non-medicinal methods the present study aimed at assessing the effect of teaching relaxation on stress, and anxiety of mothers with educable mentally retarded daughters.   Materials and MethodsThis randomized case-control field study was conducted on 36 mothers with mentally retarded daughters. In the beginning, the questionnaire "Depression, Anxiety, Stress Scales 21" was filled out for all mothers. Then, they were randomly divided into two case and control groups. Relaxation method was theoretically taught to the cases for 5 sessions together with active exercise. The controls received no education. One month after training sessions, the previous questionnaire was completed for both groups again. The obtained data was analyzed by means of SPSS software (V13) using statistical tests paired T and independent T at the significant level α=0.05.   ResultsMean score of stress, anxiety and depression before the intervention in both groups was not significantly different. But, at the end of the fourth week after relaxation training total score of stress, anxiety , and depression decreased from 19.1±10.4 to 14.1±7.6 (P

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