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Ethics code: IR.GMU.REC.1403.019
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Rahmani R, Khajehpour B, Ghanbarzadeh N, Khajavian N, khajeh S. Association between Maternal Serum Vitamin D Levels and Gestational Age at Delivery in Pregnant Women Referred to Wali Asr Hospital in Birjand in 2024: A Case-Control Study. Mod Care J 2026; 23 (4)
URL: http://mcj.bums.ac.ir/article-1-623-en.html
URL: http://mcj.bums.ac.ir/article-1-623-en.html
1- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
2- Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
3- Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
4- Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
5- Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. ,somayyehkhj@gmail.com
2- Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
3- Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
4- Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
5- Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. ,
Abstract: (97 Views)
Introduction: Numerous studies have reported a high prevalence of inadequate vitamin D status among pregnant women worldwide, and this condition has been associated with adverse pregnancy outcomes, including preterm birth. Preterm birth (PTB) is defined as spontaneous or medically induced delivery before the 37th week of gestation. Preterm infants are susceptible to a range of health complications and adverse outcomes.
Objectives: This study aimed to design a case–control study specifically to examine the association between maternal serum vitamin D levels and gestational age at delivery.
Methods: A total of 104 women referred to Wali Asr Hospital in Birjand were enrolled in the study, using a case–control design. Participants were recruited using a convenience sampling method and divided into the case group (mothers with preterm birth) and the control group (mothers with term birth (. Five-milliliter venous blood samples were obtained and subsequently centrifuged at 3000 rpm for 15 min at 28 °C. The serum was then separated and stored at −16 °C until vitamin D concentrations were determined. Data analysis was performed using SPSS, version 26 software.
Results: The case group had a significantly lower gestational age at delivery) 31.3 ± 2.92 in preterm birth group (PTB) and 38.5 ± 1.09 in the term birth group (TB), P <0.001). Vitamin D levels were also significantly lower in the preterm birth group (23.4 ± 10.81) nmol/L (in PTB and 38.0 ± 14.44(nmol/L (in TB group, p < 0.001).
Conclusion: In conclusion, vitamin D deficiency during pregnancy may be one of the factors associated with an increased risk of preterm birth.
Objectives: This study aimed to design a case–control study specifically to examine the association between maternal serum vitamin D levels and gestational age at delivery.
Methods: A total of 104 women referred to Wali Asr Hospital in Birjand were enrolled in the study, using a case–control design. Participants were recruited using a convenience sampling method and divided into the case group (mothers with preterm birth) and the control group (mothers with term birth (. Five-milliliter venous blood samples were obtained and subsequently centrifuged at 3000 rpm for 15 min at 28 °C. The serum was then separated and stored at −16 °C until vitamin D concentrations were determined. Data analysis was performed using SPSS, version 26 software.
Results: The case group had a significantly lower gestational age at delivery) 31.3 ± 2.92 in preterm birth group (PTB) and 38.5 ± 1.09 in the term birth group (TB), P <0.001). Vitamin D levels were also significantly lower in the preterm birth group (23.4 ± 10.81) nmol/L (in PTB and 38.0 ± 14.44(nmol/L (in TB group, p < 0.001).
Conclusion: In conclusion, vitamin D deficiency during pregnancy may be one of the factors associated with an increased risk of preterm birth.
Keywords: preterm birth, vitamin D deficiency
Article Types: Research Article |
Subject:
General
Received: 2026/04/28 | Accepted: 2026/08/29 | Published: 2026/10/18
Received: 2026/04/28 | Accepted: 2026/08/29 | Published: 2026/10/18
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