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Background and Aim: Preterm Premature Rupture of Membranes (PPROM) is one of the most common obstetric complications and the most difficult problem in neonatal medicine, which makes mother and her fetus at risk. It is also the main cause of mortality and morbidity in infants. Despite its frequent occurrence, there are some controversies how to treat it. This study was performed to determine the effect of antibiotic versus corticosteroid, antibiotic and tocolytic consumption for patients with PPROM (in 28-32nd week of conception) on short term neonatal outcomes.   Materials and Methods: This study was a randomized controlled clinical trial in which a total number of 64 women with PPROM were divided into two groups of case and control. In the case group, mothers received corticosteroid, antibiotic and tocolytic and the Control group just received antibiotic. By using SPSS software data were analyzed in independent t tests and chi square in P˂0.05.   Results : There were not any significant difference in the mean upgar scores (P=0.32), sex distribution (P=0.8), birth weight of neonates (P=0.67), the mean length of hospitalization (P=0.07), and prevalence of infant death (despite being less in case group) (P=0.67) in the two groups.   Conclusion : Results showed that the incidence of neonatal outcomes was not significant in the two groups but though they were less in control group. We suggest more clinical trial studies to clarify the results of corticosteroid antibiotic and tocolytic treatment on neonatal outcomes.

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