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Background and Aim: Nowadays it’s determined that stress can cause efficiency decreasing through memory disorders, angry, low self esteem, hopelessness, increasing seclusion, and also physical problems such as changing in appetite, gastrointestinal disorders and nurses who work in psychological wards aren't except in addition to special environmental conditions. Therefore this study has done to assess occupational stress and coping strategies in these groups.   Materials and Methods: A descriptive design and census sampling was used. The study population consisted of nurse who work in psychological wards with six months Work tenure in Razi hospital (n= 70). Data collecting tool has three sections, 1- Demographic information 2- stressor’s factors (physical and psycho-social) 3- coping methods, that completed by nurses. Validity and reliability determined by content validity and α- Cronbach.   Results: Wilcoxon test, showed significant difference between two group (P=0.002) and physical stressors had created more stress.   Conclusion: Although Stress decreasing benefits for staffs, also, it is benefit for employer and organization finally. Therefore, it’s necessary planning for decreasing of psycho-social stress complication such as depression and anxiety. And it’s always need to plan for necessary changes in job environment, education procedures and decreasing job stress.

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