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Background and AimNurses’ psychological wellbeing is important determiner in their professional health and it is necessary for effective caring of patients. The present study aimed at describing the role of job burnout, socioeconomic factors, and working environmental conditions in nurses’ psychological well-being.   Materials and MethodsIn this cross-sectional and descriptive study, 345 nurses were selected, through convenience sampling, from the hospitals of Isfahan University of Medical Sciences between March and July 2011. They completed Personal Well-being Scale, Burnout Clinical Subtype Questionnaire, Practice Environment Scale of Nursing Index, and Socioeconomic and Occupational Factors questionnaire. The degree of association between different variables was assessed using correlative and explanatory factors of nursing psychological well-being by means of stepwise multiple regression.   ResultsThere was a significantly positive correlation between frenetic activity, working environmental conditions, age, work hours per week, and income with psychological well-being but there was a significantly negative correlation between lack of job challenge, feeling burn out, and type of employment with psychological well-being (P

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