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Pterygium is the development of pinguecula that makes a mass of oval and palmy shape near limbus and its main treatment is surgery but due to some complications and high recurrence after syrgery, subconjunctival injection of mitomycin -C as a safe and effective treatment was detected in many researches so this study determine this purpose and prevelance in Birjand.   Materials and Methods: 30 eyes patients with pterygium referred to Vali- Asr of Birjand Hospital received 0.1 ml of 0.2 mg/ml mitomycin -subconjunectively injected into the body of the pterygium. After injection, patients were followed up at first week 3-5 months after pterygium injection. Patients were examimed at all visits for conjunctiva erythematic, epithehial defects and pterygium size reductive (regression of pterygium ). Data were gathered via 3 questionnaires. Then they were analyzed by SPSS and paired T test.(α=0.05)   Results: The complications after sub. Conjuntive mitomycin- C injection were mild chemosis and lonf discomfort and redness in the site of injection for four days that were seen in six patients (20%). No toxicity of mitomycin- C were found the size of pterygium was reduced in ( mean 0.48 mm ) 83% of cases and in all cases there were not seen progression and the amount of Astigmatism reduced (mean 0.46 diopter) in 70% cases.   Conclusion: Subconjunctival injection of mitomycin- C is an effective treatment and reduces the size of pterygium as well as redness and astigmatism.

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