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Kuhkani S, Zarghami F, Gilani N, Rashidi F, Shojaan H, Namvar L. Evaluation of Mortality and Morbidity in COVID-19 Patients Treated with NIV (Non-invasive Ventilation): A 30-Day Follow-up Study. Mod Care J 2025; 22 (2) : e157983
URL: http://mcj.bums.ac.ir/article-1-327-en.html
URL: http://mcj.bums.ac.ir/article-1-327-en.html
Sahra Kuhkani1 
, Fatemeh Zarghami2 , Neda Gilani3 , Farid Rashidi1 , Hourieh Shojaan1 , Leila Namvar *4
, Fatemeh Zarghami2 , Neda Gilani3 , Farid Rashidi1 , Hourieh Shojaan1 , Leila Namvar *4
1- Department of Pulmonary Medicine, Tabriz University of Medical Sciences, Tabriz, Iran & Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2- University of Limerick, Limerick, Ireland & Tehran University of Medical Sciences, Tehran, Iran
3- Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran & Emergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4- Department of Pulmonary Medicine, Tabriz University of Medical Sciences, Tabriz, Iran & Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,leilanamvar3@gmail.com
2- University of Limerick, Limerick, Ireland & Tehran University of Medical Sciences, Tehran, Iran
3- Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran & Emergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4- Department of Pulmonary Medicine, Tabriz University of Medical Sciences, Tabriz, Iran & Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,
Abstract: (185 Views)
Background:The COVID-19 pandemic has led to a surge in acute respiratory failure cases, necessitating effective management strategies. Non-invasive ventilation (NIV) has emerged as a treatment option; however, its efficacy and associated mortality rates remain debated.
Objectives:This study aims to evaluate the mortality and morbidity rates in COVID-19 patients treated with NIV.
Methods:We conducted a retrospective analysis of 50 patients diagnosed with COVID-19 [confirmed by positive nasopharyngeal polymerase chain reaction (PCR)] who received NIV at Imam Reza Hospital and Sina Medical Training Centers in Tabriz, Iran. Data were collected between April 2021 and January 2022, including demographic characteristics, clinical symptoms, laboratory findings, and outcomes, such as complications and mortality rates. For data analysis, we used logistic regression, the Mann-Whitney U test for comparing quantitative variables, and Fisher's exact test for qualitative variables.
Results:Among the 50 patients, 28 (56%) died during hospitalization. The median age of non-survivors was 66 years, significantly higher than that of survivors (56 years, P = 0.018). Older age and higher Quick sepsis-related organ failure assessment (QSOFA) scores were predictive of increased mortality (OR = 1.24; P = 0.001). Additionally, complications such as pneumothorax were observed in 14% of patients.
Conclusions:Our findings highlight a concerning mortality rate following NIV failure in COVID-19 patients, emphasizing the need for careful patient selection and close monitoring. Clinicians should consider early intubation for patients showing signs of NIV failure, particularly those with risk factors such as older age and high QSOFA scores.
Objectives:This study aims to evaluate the mortality and morbidity rates in COVID-19 patients treated with NIV.
Methods:We conducted a retrospective analysis of 50 patients diagnosed with COVID-19 [confirmed by positive nasopharyngeal polymerase chain reaction (PCR)] who received NIV at Imam Reza Hospital and Sina Medical Training Centers in Tabriz, Iran. Data were collected between April 2021 and January 2022, including demographic characteristics, clinical symptoms, laboratory findings, and outcomes, such as complications and mortality rates. For data analysis, we used logistic regression, the Mann-Whitney U test for comparing quantitative variables, and Fisher's exact test for qualitative variables.
Results:Among the 50 patients, 28 (56%) died during hospitalization. The median age of non-survivors was 66 years, significantly higher than that of survivors (56 years, P = 0.018). Older age and higher Quick sepsis-related organ failure assessment (QSOFA) scores were predictive of increased mortality (OR = 1.24; P = 0.001). Additionally, complications such as pneumothorax were observed in 14% of patients.
Conclusions:Our findings highlight a concerning mortality rate following NIV failure in COVID-19 patients, emphasizing the need for careful patient selection and close monitoring. Clinicians should consider early intubation for patients showing signs of NIV failure, particularly those with risk factors such as older age and high QSOFA scores.
Article number: e157983
Keywords: COVID-19, Non-invasive Ventilation (NIV), Hospital Mortality, Acute Respiratory Distress Syndrome (ARDS), Intubation, Hypoxic Respiratory Dysfunction
Article Types: Research Article |
Subject:
General
Received: 2024/11/15 | Accepted: 2025/03/11 | Published: 2025/04/15
Received: 2024/11/15 | Accepted: 2025/03/11 | Published: 2025/04/15
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