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Tabatabaei A, Babaee M, Moradi N, Nabavi M, Arshi S, Fallah S. Serum Concentration of Selenium and GPX Enzyme Activity in Iranian Children with Asthma. Mod Care J 2020; 17 (2) : e102396
URL: http://mcj.bums.ac.ir/article-1-168-en.html
URL: http://mcj.bums.ac.ir/article-1-168-en.html
Azardokht Tabatabaei1 
, Mohammad Babaee2 , Nariman Moradi3 , Mohammad Nabavi4 , Saba Arshi4 , Soudabeh Fallah *5 
, Mohammad Babaee2 , Nariman Moradi3 , Mohammad Nabavi4 , Saba Arshi4 , Soudabeh Fallah *5
1- Research center of Pediatric Infectious Disease, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
2- Department of Biochemistry, Iran University of Medical Sciences, Tehran , Iran
3- Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Asthma and Allergy Research Center, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
5- Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Hemmat High-Way, Postal Code: 14155-5983, Tehran, Iran. Email: fallah.s@iums.ac.ir
2- Department of Biochemistry, Iran University of Medical Sciences, Tehran , Iran
3- Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Asthma and Allergy Research Center, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
5- Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Hemmat High-Way, Postal Code: 14155-5983, Tehran, Iran. Email: fallah.s@iums.ac.ir
Abstract: (216 Views)
Background: Asthma is a disease with chronic airway inflammation, whereby the airway hyper-reactivity increases. Oxidative stress balance plays a critical role in asthma.
Objectives: The present study aimed to evaluate serum glutathione peroxidase (GPX) enzyme activity and selenium levels in patients with asthma.
Methods: This case-control study was conducted on 64 children aged 1 - 5 years, 32 subjects as controls, and 32 subjects with asthma who were selected randomly. The serum GPX activity and selenium levels of the studied subjects were determined spectrophotometrically.
Results: The present study showed that serum GPX activity and Selenium (Se) levels of patients with asthma were significantly lower than those of controls (P < 0.001, P < 0.05, respectively).
Conclusions: Reduction of serum GPX activity and Se concentration in patients could have a potential role in the pathogenesis and modulation of asthma. Micronutrient supplementation of Se may be beneficial in asthma.
Objectives: The present study aimed to evaluate serum glutathione peroxidase (GPX) enzyme activity and selenium levels in patients with asthma.
Methods: This case-control study was conducted on 64 children aged 1 - 5 years, 32 subjects as controls, and 32 subjects with asthma who were selected randomly. The serum GPX activity and selenium levels of the studied subjects were determined spectrophotometrically.
Results: The present study showed that serum GPX activity and Selenium (Se) levels of patients with asthma were significantly lower than those of controls (P < 0.001, P < 0.05, respectively).
Conclusions: Reduction of serum GPX activity and Se concentration in patients could have a potential role in the pathogenesis and modulation of asthma. Micronutrient supplementation of Se may be beneficial in asthma.
Article number: e102396
Article Types: Research Article |
Subject:
General
Received: 2020/03/7 | Accepted: 2020/06/22 | Published: 2020/07/12
Received: 2020/03/7 | Accepted: 2020/06/22 | Published: 2020/07/12
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