Volume 16, Issue 1 (1-2019)                   | Back to browse issues page

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Ghorbani Abdi Saedabad A, Rezaie R, Moosavi S Y J, Anani Sarab G, Malekaneh M, Houshyar R. Serum Levels of Insulin-Like Growth Factor 1, Interlukin-6, Heat-Shock Proteins-27 and Heat-Shock Proteins-60 as Inflammatory Markers of Type 2 Diabetes: A Case-Control Study. Mod Care J 2019; 16 (1)
URL: http://mcj.bums.ac.ir/article-1-135-en.html
Serum Levels of Insulin-Like Growth Factor 1, Interlukin-6, Heat-Shock Proteins-27 and Heat-Shock Proteins-60 as Inflammatory Markers of Type 2 Diabetes: A Case-Control Study
Arash Ghorbani Abdi Saedabad1 , Reyhane Rezaie2 , Seyed Yoosef Javad Moosavi1 , Gholamraza Anani Sarab3 , Mohammad Malekaneh3 , Reyhaneh Houshyar *4
1- Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
2- Mashhad University of Medical Sciences, Mashhad, Iran
3- Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
4- MSc, PhD Cellular and Molecular Research Center, Birjand University of Medical Sciences, P.O. Box: 9717853577, Birjand, Iran. Email: reyhaneh.houshyar@gmail.com
Abstract:   (210 Views)
Background: Inflammatory biomarkers such as insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), and heat-shock proteins 27 (HSP-27) and 60 (HSP-60) may contribute to the development of type II diabetes mellitus. This study aimed to compare these inflammatory biomarkers among individuals with and without type II diabetes mellitus. Methods: This case-control study was conducted on fifty patients with type II diabetes mellitus and fifty individuals without it. None of the participants suffered from inflammatory diseases like rheumatoid arthritis and systemic lupus erythematosus. Patients in the diabetic group were matched with individuals in the non-diabetic group respecting their age and gender. Serum levels of IGF-1, IL-6, HSP-27, and HSP-60 were measured through enzyme-linked immunosorbent assay kits. Data were analyzed using the SPSS software (v. 15.0). Results: The mean serum levels of IGF-1, IL-6, HSP-27, and HSP-60 in the diabetic group were significantly greater than the non-diabetic group (P < 0.05). Conclusions: This study shows that IGF-1, IL-6, HSP-27, and HSP-60 inflammatory markers play roles in the development of type II diabetes mellitus.
Keywords: Diabetes Mellitus Type 2, Insulin-Like Growth Factor 1, Interleukin-6, Heat-Shock Proteins, Inflammation
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Article Types: Research Article | Subject: General
Received: 2026/01/10 | Accepted: 2019/01/15 | Published: 2019/01/15
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