fa تأثیر مصرف طولانی‌مدّت سدیم بنزوات در دوران قبل وحین بارداری بر روی شاخص‌های رشد جنین موش سوری نژاد Balb/C General پژوهشي Research Article Background and Aim: Food additives, such as sodium benzoate (SB), are used in many food products and drugs to postpone the growth of microrganisms. The aim of the present study was to evaluate the effects of long term consumption of SB on the growth indexes of Balb/c mice. Materials and Methods: In this experimental study, 30 female Balb/c mice were divided into 2 experimental (I, II) and one control groups. The experimental groups (I, II) daily received 280 and 560 mg/kg of SB intrapretoneally, respectively. The control group received normal saline in the same way. All injections were done during 10 days before gestation, and then, between the 6th and the 15th of gestational days (GD6-15). The mice underwent cesarean section on GD 18 and their embryos were removed. Then, weighing the embryos and measuring their length were done. The embryos were stained with alizarin red and alcian blue and observed by means of a stereomicroscope. The obtained data was analyzed using SPSS software and statistical tests one-way variance analysis, Tukey, and c 2 at the significant level P<0.05. Result: Mean weight and crown-rump of the fetuses in the experimental group II significantly decreased in comparison with the experimental group I and the control group. The fetal resorption in the experimental groups I and II significantly decreased in comparison with the control group (P=0.04). Conclusion: SB consumption before and during pregnancy can probably induce negative changes of fetal indexes . Thus, it is recommended that pregnant women cautiously use food stuffs containing sodium benzoate, as far as possible. Sodium benzoate,Growth and Development,Food Additives,Mice,Inbred BALB C. 173 180 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-559&slc_lang=fa&sid=1 Mohammad Afshar محمد افشار 10031947532846004126 10031947532846004126 No Professor, Department of Anatomy, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran استاد گروه علوم تشریحی، دانشکده پزشکی،دانشگاه علوم پزشکی بیرجند، ایران Adel Moallem سید عادل معلم 10031947532846004127 10031947532846004127 No Associate Professor, Department of Pharmacodynamics & Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran دانشیار گروه فارماکودینامی و سم شناسی، دانشکده داروسازی، عضومرکز تحقیقات علوم دارویی و مرکز تحقیقات سم شناسی دانشگاه علوم پزشکی مشهد، ایران Mohammad Mehdi Hasanzadeh Taheri محمدمهدی حسن‌زاده طاهری 10031947532846004128 10031947532846004128 No Associate Professor, Department of Anatomy, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran دانشیار گروه علوم تشریحی،دانشکده پزشکی، دانشگاه علوم پزشکی بیرجند، ایران Marzieh Shahsavan مرضیه شاهسون 10031947532846004129 10031947532846004129 Yes Department of Biology, Faculty of Basic Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran marjan. Email: shahsavan@yahoo.com کارشناس ارشد زیست شناسی سلولی-تکوینی، گروه زیست شناسی، دانشکده علوم پایه، دانشگاه آزاد اسلامی، واحد مشهد، ایران. تلفن: 0518787234 پست الکترونیک: marjan.shahsavan@yahoo.com Farzaneh Sukhtanloo فرزانه سوختانلو 10031947532846004130 10031947532846004130 No Student of Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran دانشجوی پزشکی،دانشکده پزشکی،دانشگاه علوم پزشکی بیرجند، ایران Fatemeh Salehi فاطمه صالحی 10031947532846004131 10031947532846004131 No BS of Midwifery, Birjand University of Medical Sciences, Birjand, Iran کارشناس مامایی، دانشگاه علوم پزشکی بیرجند، ایران