en General پژوهشي Research Article Background: Nurses experience considerable stress due to their difficult working conditions. Experiencing stress over a long period of time can influence mental health. Objectives: This study aimed at predicting nurses&rsquo; mental health based on their job burnout, perceived social support, and psychological hardiness. Methods: This correlational study was done during year 2015 on 400 individuals, who worked in public hospitals located in Tehran, Iran. All nurses completed Maslach and Jackson&rsquo;s job Burnout inventory, Zimet et al.&rsquo;s Perceived Social support scale, Kobasa&rsquo;s psychological hardiness inventory, and Goldberg and Hillier&rsquo;s general health questionnaire. The data were analyzed using the SPSS software (v. 19.0) through running the Pearson correlation analysis and multiple regression analysis at a significance level of less than 0.01. Results: Nurses&rsquo; mental health was positively correlated with their job burnout (r = 0.37) and negatively with their perceived social support (r = -0.56) and psychological hardiness (r = -0.53; P < 0.01). Job burnout, perceived social support and psychological hardiness explained 54.9% of the total variance of nurses&rsquo; mental health (R2 = 0.549). Conclusions: Given the significant role of job burnout, perceived social support and psychological hardiness in predicting nurses&rsquo; mental health, manipulating these variables can help improve nurses&rsquo; mental health. Job Burnout,Perceived Social Support,Psychological Hardiness,Mental Health,Nurses 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-29&slc_lang=en&sid=1 Nahid Babaeiamiri 10031947532846002236 10031947532846002236 Yes Nahid Babaeiamiri, Department of Psychology, College of Management and Accounting, Yadegar-e-Imam Khomeini (RAH) Shahre Ray Branch, Islamic Azad University, Tehran, IR Iran. Tel: +98-9125504779, E-mail: nbabaieamiry@yahoo.com