fa اثرات محافظتی عصاره آبی عناب بر شاخصهای رشدی جنین‌های موش در معرض داروی کاربامازپین General پژوهشي Research Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong>Background and Aim: </strong>Carbamazepine (CBZ) is an anticonvulsant drug that is widely used, primarily to treat seizures. One of the side effects of this medication during pregnancy is the reduced fetal growth. The jujube has been widely used in traditional medicine because of its special compound. The purpose of this study was to evaluate the preventive effects of aqueous extract of jujube on growth index of mice fetuses exposed to Carbamazepine.<br> <strong>Materials and Methods: </strong>In this study, 100 Balb/C mice (28-30 gr; 8-9 weeks-old) were divided into eight experimental and two control groups. Experimental groups (І, ІІІ, V) and (ІІ, IV, VI) received daily intraperitoneal injections of 50 and 100 mg/kg of CBZ, respectively. Experimental groups (ІІІ, IV) and groups (V, VI) were gavaged doses of 200 and 400 mg/kg of aqueous extract of jujube respectively. Groups VII and VIII received only doses of 200 and 400 mg/kg of aqueous extract of jujube respectively. Control groups І and ІІ were gavaged to normal saline and tween respectively. Injections were done on 0 to 15 gestational days (GD), and aqueous extract was gavaged along with CBZ starting 10 days prior to gestation. On GD 18, fetuses were removed for weighing and crown-rump measuring. Data were analyzed by ANOVA and Tukey tests using SPSS (version 18) at 0.05%.<br> <strong>Results</strong>: Average weight and body length of fetuses in experimental groups I and II, that received CBZ, significantly reduced compared with control groups. In the fetuses of experimental groups V (1.20&plusmn;0.38) and VI (1.21&plusmn;0.21 gr) that recieved jujube extract (400 mg/day) with CBZ, the mean weight of these fetuses increased meaningfully in comparison with the experimental groups I (0.93&plusmn;0.19 gr) and II (0.92&plusmn;0.26 gr) respectively.<br> <strong>Conclusion</strong>: This study showed that aqueous extracts of jujube can have preventive effects on reducing effect of CBZ on birth fetal weight.</span></span></div> Growth Index,Jujube,Carbamazepine,Mice 145 152 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-454&slc_lang=fa&sid=1 Mohammad Afshar محمد افشار No Professor, Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Science, Medical Toxicology Research Center, Mashhad University of Medical Science, Iran استاد گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند و عضو مرکز تحقیقات سم شناسی دانشکده پزشکی دانشگاه علوم پزشکی مشهد. ایران Hossein Nahangi حسین نهنگی No Associate Professor, Department of Anatomy, Faculty of Medicine, Yazd University of Medical Science, Yazd, Iran دانشیار گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی یزد. یزد، ایران Mohammad Mehdi Hassanzade Taheri محمدمهدی حسن زاده طاهری No Associate Professor, Department of Anatomy, Faculty of Medicine, Birjand University of Medical Science, Birjand, Iran دانشیار گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند. بیرجند، ایران Mohammad Hasanpour محمد حسن پور No Associated Professor, Department of Physiology and Pharmacology, Faculty of Medicine, Birjand University of Medical Science, Birjand, Iran. استادیار گروه آموزشی فیزیولوژی و فارماکولوژی، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند. بیرجند، ایران MohammadReza Doostabadi محمدرضا دوست آبادی Yes Mohammad Reza Doostabadi, M.Sc. Student of Anatomy, Faculty of Medicine, Yazd University of Medical Sciences, Yazd, Iran. Email: doostabadim@yahoo.com محمد رضا دوست آبادی، دانشجوی کارشناسی ارشد علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی یزد. یزد، ایران. تلفن:09153661375 پست الکترونیک:doostabadim@yahoo.com