en General گزارش مختصر Brief Report <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong>Background:</strong> Evidence on the safety and efficacy of phosphate (P) replacement in hypophosphatemic intensive care unit (ICU) patients remains limited.<br> <strong>Objectives:</strong> To evaluate the efficacy and safety of a 24-hour weight-based intravenous phosphate replacement protocol.<br> <strong>Methods:</strong> Adult ICU patients with hypophosphatemia received potassium acid phosphate (25 mL) diluted in 500 mL of saline or 5% glucose, administered via infusion pump. Dosing was 0.3 mmol/kg/24 h for mild hypophosphatemia (0.65 - 0.73 mmol/L) and 0.6 mmol/kg/24 h for moderate to severe cases (&le; 0.64 mmol/L). Phosphate levels were measured every 24 hours. Efficacy was defined as normalization of phosphate within 24 hours. Safety outcomes included hypocalcemia, hypotension, hyperphosphatemia, hyperkalemia, and acute kidney injury.<br> <strong>Results: </strong>Among 134 patients (aged 67.6 &plusmn; 14.6 years; 55% female; median APACHE II median 18), 197 hypophosphatemia episodes were treated. Phosphate normalized within 24 hours in 121 episodes (61%). Mild adverse events occurred in 28 patients (21%); no severe complications were reported.<br> <strong>Conclusions: </strong>This protocol is not a replacement for standard guidelines in symptomatic hypophosphatemia and unstable patients. It proved effective and generally safe in critically ill patients with mild to severe hypophosphatemia, offering a feasible approach in resource-limited ICU settings where oral formulations are unavailable and frequent laboratory monitoring is unfeasible.</span></span></div> Hypophosphatemia,Intensive Care Units,Repletion 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-325&slc_lang=en&sid=1 Washington Lima Júnior 10031947532846004866 10031947532846004866 No Nutrition and Diet Service, Governor Israel Pinheiro Hospital, Minas Gerais State Employee Pension Institute, Belo Horizonte, Minas Gerais, Brazil Debora Cerqueira Calderaro 10031947532846004867 10031947532846004867 Yes Department of Locomotor System, Falculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. Email: dccalderaro@gmail.com Rogerio Passos 10031947532846004868 10031947532846004868 No Intensive Care Unit, São Rafael Hospital, Salvador, Bahia, Brazil Margaret Côrte 10031947532846004869 10031947532846004869 No Spech Therapy Nucleus, Governor Israel Pinheiro Hospital , Minas Gerais State Employee Pension Institute, Belo Horizonte, Minas Gerais, Brazil José Adalberto Leal 10031947532846004870 10031947532846004870 No Nutrition and Diet Service, Governor Israel Pinheiro Hospital, Minas Gerais State Employee Pension Institute, Belo Horizonte, Minas Gerais, Brazil Marcelo Oliveira Mayrink 10031947532846004871 10031947532846004871 No Hospital Brasília, Brasília, Brazil Gilda Aparecida Ferreira 10031947532846004872 10031947532846004872 No Department of Locomotor System, Falculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazi