en General پژوهشي Research Article Background: Adverse drug reactions (ADRs) are one of the leading causes of mortality and morbidity. Avoiding adverse reactions requires comprehensive knowledge about how they can be monitored, controlled, and reported.Objectives: The current study aimed to evaluate the knowledge, attitude, practices, and perceptions of the health care professionals concerning the adverse drug reactions monitoring and reporting in Lahore, Pakistan.Methods: A prospective cross-sectional study was conducted in Lahore, Pakistan, from October 2018 to December 2018. Descriptive statistics were obtained and the Pearson chi-square test was used to analyze the association between categorical variables.Results: In total, 150 pharmacists, physicians, and nurses were approached, that 40, 39, and 46 of them responded, respectively. Almost 95% pharmacists, 17.3% of nurses, and 58.9% of physicians correctly defined the “pharmacovigilance”, while 70, 10, and 30.5%, respectively, defined ADRs correctly. The current study revealed that 87% of pharmacists, 82.5% of physicians, and 82.6% of nurses had a history of identifying ADR in patients. Out of which only 52, 41, and 19% of pharmacists, physicians, and nurses had a history of reporting adverse drug reactions, respectively.Conclusions: This study revealed inadequate knowledge of health care professionals. Most healthcare professionals were motivated to report identified ADRs. However, the responsibility lies with the governing authorities to provide them with a suitably efficient platform to practice proper ADR reporting and monitoring. Educational campaigns and training, financial incentives, and simplification of the reporting process might change the levels of knowledge and attitude. Pharmacovigilance,Healthcare Professional,ADR Monitoring,ADR Reporting 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-153&slc_lang=en&sid=1 Furqan Hashmi 10031947532846001991 10031947532846001991 Yes University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, Pakistan. Email: furqan.pharmacy@pu.edu.pk Sara Mustafa Khan 10031947532846001992 10031947532846001992 No Akhtar Saeed College of Pharmacy, Lahore, PAkistan Sulman Qureshi 10031947532846001993 10031947532846001993 No Akhtar Saeed College of Pharmacy, Lahore, PAkistan Usman Rashid Malik 10031947532846001994 10031947532846001994 No School of Pharmacy, Xi’an Jiaotong University, Xi’an, China Naveel Atif 10031947532846001995 10031947532846001995 No School of Pharmacy, Xi’an Jiaotong University, Xi’an, China Fahad Saleem 10031947532846001996 10031947532846001996 No Faculty of Pharmacy, University of Balochistan, Quetta, Pakistan