en General پژوهشي Research Article Background: Inflammatory biomarkers such as insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), and heat-shock proteins 27 (HSP-27) and 60 (HSP-60) may contribute to the development of type II diabetes mellitus. This study aimed to compare these inflammatory biomarkers among individuals with and without type II diabetes mellitus. Methods: This case-control study was conducted on fifty patients with type II diabetes mellitus and fifty individuals without it. None of the participants suffered from inflammatory diseases like rheumatoid arthritis and systemic lupus erythematosus. Patients in the diabetic group were matched with individuals in the non-diabetic group respecting their age and gender. Serum levels of IGF-1, IL-6, HSP-27, and HSP-60 were measured through enzyme-linked immunosorbent assay kits. Data were analyzed using the SPSS software (v. 15.0). Results: The mean serum levels of IGF-1, IL-6, HSP-27, and HSP-60 in the diabetic group were significantly greater than the non-diabetic group (P < 0.05). Conclusions: This study shows that IGF-1, IL-6, HSP-27, and HSP-60 inflammatory markers play roles in the development of type II diabetes mellitus. Diabetes Mellitus Type 2,Insulin-Like Growth Factor 1,Interleukin-6,Heat-Shock Proteins,Inflammation 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-114&slc_lang=en&sid=1 Arash Ghorbani Abdi Saedabad 10031947532846002169 10031947532846002169 No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran Reyhane Rezaie 10031947532846002170 10031947532846002170 No Mashhad University of Medical Sciences, Mashhad, Iran Seyed Yoosef Javad Moosavi 10031947532846002171 10031947532846002171 No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran Gholamraza Anani Sarab 10031947532846002172 10031947532846002172 No Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran Mohammad Malekaneh 10031947532846002173 10031947532846002173 No Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran Reyhaneh Houshyar 10031947532846002174 10031947532846002174 Yes MSc, PhD Cellular and Molecular Research Center, Birjand University of Medical Sciences, P.O. Box: 9717853577, Birjand, Iran. Email: reyhaneh.houshyar@gmail.com