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Modern Care Journal
سه شنبه 12 آبان 1405
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دوره 11، شماره 2 - ( 4-1393 )
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Afshar M, Nahangi H, Hassanzade Taheri M M, Hasanpour M, Doostabadi M. Preventive effects of aqueous extract of jujube on growth index of mice fetuses exposed to Carbamazepine. , Mod Care J. 2014; 11 (2) :145-152
URL: http://mcj.bums.ac.ir/article-1-475-fa.html
URL: http://mcj.bums.ac.ir/article-1-475-fa.html
افشار محمد، نهنگی حسین، حسن زاده طاهری محمدمهدی، حسن پور محمد، دوست آبادی محمدرضا. اثرات محافظتی عصاره آبی عناب بر شاخصهای رشدی جنین‌های موش در معرض داروی کاربامازپین. , مراقبت های نوین. 1393; 11 (2) :145-152
1- استاد گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند و عضو مرکز تحقیقات سم شناسی دانشکده پزشکی دانشگاه علوم پزشکی مشهد. ایران
2- دانشیار گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی یزد. یزد، ایران
3- دانشیار گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند. بیرجند، ایران
4- استادیار گروه آموزشی فیزیولوژی و فارماکولوژی، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند. بیرجند، ایران
5- محمد رضا دوست آبادی، دانشجوی کارشناسی ارشد علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی یزد. یزد، ایران. تلفن:09153661375 پست الکترونیک:doostabadim@yahoo.com
2- دانشیار گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی یزد. یزد، ایران
3- دانشیار گروه آموزشی علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند. بیرجند، ایران
4- استادیار گروه آموزشی فیزیولوژی و فارماکولوژی، دانشکده پزشکی دانشگاه علوم پزشکی بیرجند. بیرجند، ایران
5- محمد رضا دوست آبادی، دانشجوی کارشناسی ارشد علوم تشریح، دانشکده پزشکی دانشگاه علوم پزشکی یزد. یزد، ایران. تلفن:09153661375 پست الکترونیک:doostabadim@yahoo.com
چکیده: (446 مشاهده)
Background and Aim: Carbamazepine (CBZ) is an anticonvulsant drug that is widely used, primarily to treat seizures. One of the side effects of this medication during pregnancy is the reduced fetal growth. The jujube has been widely used in traditional medicine because of its special compound. The purpose of this study was to evaluate the preventive effects of aqueous extract of jujube on growth index of mice fetuses exposed to Carbamazepine.
Materials and Methods: In this study, 100 Balb/C mice (28-30 gr; 8-9 weeks-old) were divided into eight experimental and two control groups. Experimental groups (І, ІІІ, V) and (ІІ, IV, VI) received daily intraperitoneal injections of 50 and 100 mg/kg of CBZ, respectively. Experimental groups (ІІІ, IV) and groups (V, VI) were gavaged doses of 200 and 400 mg/kg of aqueous extract of jujube respectively. Groups VII and VIII received only doses of 200 and 400 mg/kg of aqueous extract of jujube respectively. Control groups І and ІІ were gavaged to normal saline and tween respectively. Injections were done on 0 to 15 gestational days (GD), and aqueous extract was gavaged along with CBZ starting 10 days prior to gestation. On GD 18, fetuses were removed for weighing and crown-rump measuring. Data were analyzed by ANOVA and Tukey tests using SPSS (version 18) at 0.05%.
Results: Average weight and body length of fetuses in experimental groups I and II, that received CBZ, significantly reduced compared with control groups. In the fetuses of experimental groups V (1.20±0.38) and VI (1.21±0.21 gr) that recieved jujube extract (400 mg/day) with CBZ, the mean weight of these fetuses increased meaningfully in comparison with the experimental groups I (0.93±0.19 gr) and II (0.92±0.26 gr) respectively.
Conclusion: This study showed that aqueous extracts of jujube can have preventive effects on reducing effect of CBZ on birth fetal weight.
Materials and Methods: In this study, 100 Balb/C mice (28-30 gr; 8-9 weeks-old) were divided into eight experimental and two control groups. Experimental groups (І, ІІІ, V) and (ІІ, IV, VI) received daily intraperitoneal injections of 50 and 100 mg/kg of CBZ, respectively. Experimental groups (ІІІ, IV) and groups (V, VI) were gavaged doses of 200 and 400 mg/kg of aqueous extract of jujube respectively. Groups VII and VIII received only doses of 200 and 400 mg/kg of aqueous extract of jujube respectively. Control groups І and ІІ were gavaged to normal saline and tween respectively. Injections were done on 0 to 15 gestational days (GD), and aqueous extract was gavaged along with CBZ starting 10 days prior to gestation. On GD 18, fetuses were removed for weighing and crown-rump measuring. Data were analyzed by ANOVA and Tukey tests using SPSS (version 18) at 0.05%.
Results: Average weight and body length of fetuses in experimental groups I and II, that received CBZ, significantly reduced compared with control groups. In the fetuses of experimental groups V (1.20±0.38) and VI (1.21±0.21 gr) that recieved jujube extract (400 mg/day) with CBZ, the mean weight of these fetuses increased meaningfully in comparison with the experimental groups I (0.93±0.19 gr) and II (0.92±0.26 gr) respectively.
Conclusion: This study showed that aqueous extracts of jujube can have preventive effects on reducing effect of CBZ on birth fetal weight.
نوع مقاله: پژوهشي |
دریافت: 1392/12/8 | پذیرش: 1393/4/7 | انتشار: 1393/5/4
دریافت: 1392/12/8 | پذیرش: 1393/4/7 | انتشار: 1393/5/4
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