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Background and AimMultiple Sclerosis is one of the most prevalent diseases of the central nervous system that for some reasons, including occurrence during the youth and not having a definite treatment causes depression in patients associated with disability and recurrence. The present study aimed at evaluating impact of peer education on depression in patients with multiple sclerosis in 2011.   Materials and MethodsIn this semi-experimental study, after non- randomized sampling, the selected subjects were randomly assigned into two experimental and control groups. In the beginning, five educational sessions were held for the peer group to prepare them for their job. Then, after the preparation of the peer group, they held six educational sessions for the experimental group during two months. Data collection tools were demographic information, DASS 21, and a self-administered questionnaire. The obtained data was analysed by means of statistical tests c 2 , paired t, and independent t at the significant level P

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