en General پژوهشي Research Article Background and Aim:Aging population is increasing progressively. Therefore, determining factors behind their life satisfaction is among research priorities. The present study aimed to evaluate the correlation of grandparent-grandchild relationship and older adults&rsquo; life satisfaction. Methods: This cross-sectional descriptive-correlational study was done on 377 older adults who were 60 years of age or older and lived in Kashan, Iran. Participants were selected via multistage sampling. A researcher-made questionnaire was used for the assessment of grandparent-grandchild relationship and life satisfaction. Collected data were entered into the SPSS software (v. 23.0) and analyzed by running the Pearson correlation and multiple linear regression analyses. Results: Participants aged 70.24 &plusmn; 8.20, on average, and were mostly female (62%). The mean scores of the association, emotional, and functional attachment dimensions of grandparent-grandchild relationship were 56.81 &plusmn; 13.18, 77.75 &plusmn; 16.64, and 68.22 &plusmn; 15.71, respectively. Moreover, the mean of life satisfaction was 81.40 &plusmn; 17.01. Life satisfaction was positively correlated with the association, emotional, and functional attachments (r = 0.31, 0.41, 0.35, respectively; P < 0.001). Moreover, regression analysis illustrated that the emotional and functional attachments significantly predicted 20% of the total variance of life satisfaction (P < 0.001). The strongest predictor of life satisfaction was emotional attachment. Conclusions: Grandparent-grandchild relationship can significantly improve older adults&rsquo; life satisfaction. Therefore, strategies are needed to strengthen this relationship. Grandparents,Grandchildren,Life Satisfaction,Aging 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-67&slc_lang=en&sid=1 Mahboube Mahdi Vidouje 10031947532846003573 10031947532846003573 No MSc, Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, IR Iran Yadollah Abolfathi Momtaz 10031947532846003574 10031947532846003574 Yes Yadollah Abolfathi Momtaz (PhD), Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Malaysian Research Institute on Ageing (MyAgeing), Universiti Putra Malaysia. E-mail: drmomtaz@gmail.com Mahshid Foroughan 10031947532846003575 10031947532846003575 No MD, Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, IR Iran Mahin Sadat Azimi 10031947532846003576 10031947532846003576 No MD, MPH, Elderly Health Office, Ministry of Health and Medical Education of Islamic Republic of Iran Seyyed Alireza Moravveji 10031947532846003577 10031947532846003577 No MD, Department of Community Medicine, Faculty of Medicine, Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, IR Iran Leali Mohandes Mojarrad 10031947532846003578 10031947532846003578 No MD, Department of Community Medicine, Faculty of Medicine, Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, IR Iran Halime Zareii 10031947532846003579 10031947532846003579 No MSc, Elderly Health Office, Deputy of Health, Kashan University of Medical Sciences, Kashan, IR Iran Robab Sahaf 10031947532846003580 10031947532846003580 No MD, PhD, Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, IR Iran