en General پژوهشي Research Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong>Background:</strong> Several epidemiological studies have investigated the association between vitamin D deficiency and abnormal liver enzyme levels and type 2 diabetes (T2D) with inconsistent conclusions.<br> <strong>Objectives: </strong>The current research aims to evaluate the effect of eight weeks of vitamin D consumption alongside exercise in water on liver enzymes and the mental health of women with type 2 diabetes.<br> <strong>Methods:</strong> Forty women with type 2 diabetes aged 40 to 60 were divided into four groups of 10 subjects: (1) exercise in water and vitamin D supplementation, (2) exercise in water, (3) vitamin D supplementation, and (4) control group. The water exercise group performed three exercise sessions per week for eight weeks (Borg scale of 14), and vitamin D supplementation groups consumed 50,000 (IU) vitamin D every week. Liver enzymes and mental health (Beck&#39;s Stress and Anxiety (BAI) questionnaire (21 questions, alpha Cronbach 0.92) and depression (BDI-II) questionnaires (21 questions, alpha Cronbach 0.87)) were administered before and after eight weeks of training. The data were analyzed using descriptive and inferential statistics by SPSS software version 21. Kolmogorov-Smirnov test and one-way analysis of variance and paired t-test were used to analyze the data at a significance level of 0.05.<br> <strong>Results: </strong>Aspartate aminotransferase and alanine aminotransferase decreased significantly after eight weeks in the vitamin D + water exercise and water exercise groups (P < 0.05). Moreover, depression and stress scores significantly decreased after the intervention in the vitamin D + water exercise and water exercise groups (P < 0.05).<br> <strong>Conclusions:</strong> The findings demonstrated that exercise in water plus vitamin D consumption improved anthropometric indices and liver enzymes and alleviated depression and stress in patients with type 2 diabetes. These two interventions can be combined to reduce type 2 diabetes complications.</span></span></div> Water Training,Vitamin D,Mental Health 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-252&slc_lang=en&sid=1 Mona Salarinia 10031947532846005127 0009-0007-1953-8416 No Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Guilan, Iran Mohammad Azizi azizimihammad@gmail.com 10031947532846005128 10031947532846005128 Yes Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran Worya Tahmasebi 10031947532846005129 10031947532846005129 No Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran Hadi Khalvandi 10031947532846005130 0009-0003-3555-0045 No Member of Medical Council of Iran, Kermanshah University of Medical Sciences, Kermanshah, Iran