en General پژوهشي Research Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong>Background:</strong> With the onset of the coronavirus disease 2019 (COVID-19) pandemic in December 2019, healthcare systems faced an unprecedented challenge. Medical and paramedical students are the front-line warriors in this combat.<br> <strong>Objectives: </strong>This study aimed to assess COVID-19 knowledge, attitudes, and practice among the students of Birjand University of Medical Sciences, Iran, in 2020.<br> <strong>Methods: </strong>This cross-sectional analytical study was carried out on 329 students who passed the microbiology course from October 2020 to March 2021. The data collection tool was a researcher-made questionnaire consisting of four sections: demographic data, COVID-19-related knowledge, attitudes towards COVID-19, and participants&rsquo; practice. Finally, statistical analysis was performed in SPSS software version 19, and a significance level of 0.05 was considered in all tests.<br> <strong>Results:</strong> A total of 329 medical, dentistry, pharmacy, and laboratory sciences students participated in this study. The mean score of COVID-19 knowledge was 10.26 &plusmn; 1.21 (out of 12). Among the participants, 103 (31.3%) individuals expressed being in crowded places in recent days, and 324 (98.5%) of them confirmed wearing masks. More than half of the students had positive attitudes towards COVID-19 control. The average knowledge was higher in females and medical and laboratory sciences students (P = 0.008). Also, the students&#39; knowledge was inversely related to their practice of wearing a mask (P = 0.015).<br> <strong>Conclusions:</strong> While students had a high level of COVID-19 knowledge, they had some misconceptions that should be included in educational programs. Students of medical sciences should be responsible for preventive behaviors and strive to be good role models for others.</span></span></div> Microbiology,Medical Students,Practice,Attitude,Knowledge,COVID-19 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-193&slc_lang=en&sid=1 Majid Zare Bidaki 10031947532846005365 10031947532846005365 No Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran Hamed Aramjoo 10031947532846005366 10031947532846005366 No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran Malihe Ram 10031947532846005367 10031947532846005367 No Valiasr Hospital Clinical Research Center, Birjand University of Medical Sciences, Birjand, Iran Hadis Enayati 10031947532846005368 10031947532846005368 Yes Student Research Committee, Birjand University of Medical Sciences, Ghafari Avenue, Birjand, Iran. Email: hadissenayati@gmail.com Azadeh Ebrahimzadeh 10031947532846005369 10031947532846005369 No Infectious Diseases Research Center, Birjand University of Medical Sciences, Ghafari Avenue, Birjand, Iran. Email: mr14436@yahoo.com