en General پژوهشي Research Article Background:&nbsp;Cardiovascular Disease (CVD) is one of the most important causes of mortality and morbidity in developed and developing countries.Objectives:&nbsp;This study aimed to evaluate the risk factors associated with the extent of coronary vessel involvement across the spectrum of Coronary Artery Disease (CAD) in patients referring to the Cardiac Ward of Vali-Asr Hospital of Birjand, Iran.Methods:&nbsp;A cross-sectional study was conducted on 3,394 patients undergoing coronary angiography at the Cardiac Ward of Vali-Asr Hospital of Birjand, Iran, in 2011-2015. Subjects were assigned to four groups in terms of the extent of coronary vessel involvement: Normal CAD, non-significant CAD, CAD, and non-obstructive CAD. Adjusted odds ratios and 95% confident intervals were calculated by including all variables with P values < 0.05 into the multivariate model to control for confounding factors. Data were analyzed using SPSS version 22.Results:&nbsp;Among male and female patients, those aged 45-65 years needed angiography more than other groups. Multiple logistic regression analysis showed that diabetes, male gender, FBS, and history of hypertension significantly increased the likelihood of coronary vessel involvement (P &le; 0.05).Conclusions:&nbsp;The findings of the present study imply that age, male gender, FBS, and history of hypertension are the independent risk factors for the extent of coronary vessel involvement in CAD and non-significant CAD groups. To reduce the rates and consequences of CAD, it is paramount to control cardiovascular risk factors, screen susceptible populations at risk, and improve coronary interventional services. Risk Factors,Coronary Artery Stenosis,Coronary Artery Stenosis 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-159&slc_lang=en&sid=1 Ali Moezi 10031947532846001949 10031947532846001949 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Maryam Soltani 10031947532846001950 10031947532846001950 No Razi Clinical Research Development Unit (RCRDU), Birjand University of Medical Sciences, Birjand, Iran Toba Kazemi 10031947532846001951 10031947532846001951 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Saeede Khosravi Bizahem 10031947532846001952 10031947532846001952 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Nasrin Amirabadizadeh 10031947532846001953 10031947532846001953 No Razi Clinical Research Development Unit (RCRDU), Birjand University of Medical Sciences, Birjand, Iran Nazanin Hanafi 10031947532846001954 10031947532846001954 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Neda Partovi 10031947532846001955 10031947532846001955 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Hamid Reza Mashreghimoghadam 10031947532846001956 10031947532846001956 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Mohammad Yousef Ghoddusi 10031947532846001957 10031947532846001957 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Majid Jafarnejad 10031947532846001958 10031947532846001958 No Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Nahid Azdaki 10031947532846001959 10031947532846001959 Yes Department of Cardiology ,Cardiovascular Diseases Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Email: nahidazdaki@yahoo.com