en General پژوهشي Research Article Background and Objectives: Hepatitis B is associated with different physical and psychological complications. This study sought to evaluate the effects of cognitive behavioral therapy on the quality of life among patients with hepatitis B. Methods: In this quasi-experimental study, 60 patients with hepatitis B were conveniently recruited from a private infectious disease clinic in Birjand, Iran. The patients were randomly allocated to either a control (n = 30) or an intervention (n = 30) group. Patients in the intervention group received cognitive behavioral therapy in eight 45-minute sessions while their counterparts received no cognitive behavioral therapy. All patients completed the 36-item Short Form Survey both before and after the intervention. The SPSS software (v. 15.0) was used to analyze the data by running the paired-sample t, independent-sample t, Wilcoxon signed-rank, and Mann-Whitney U test at a significance level of less than 0.05. Results: In the intervention group, the scores of the social functioning and general health domains of quality of life significantly decreased while the score of the emotional well-being domain significantly increased after the intervention (P < 0.05). However, the mean scores of the other domains did not change significantly (P > 0.05). Moreover, in the control group, the scores of quality of life and its social functioning and general health domains significantly decreased (P < 0.05), while the scores of the other dimensions did not change significantly (P > 0.05). The groups did not significantly differ from each other respecting the pretest-posttest mean scores of the quality of life and its domains (P > 0.05). Conclusions: This study suggests that cognitive behavioral therapy has no significant effect on the quality of life but significantly improves emotional well-being among patients with hepatitis B. Hepatitis B,Quality of Life,Cognitive Behavioral Therapy 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-102&slc_lang=en&sid=1 Nasrin Riyahi 10031947532846002224 10031947532846002224 No Msc Student of Clinical Psychology, Islamic Azad University, Birjand Branch, Birjand, Iran Masood Ziaee 10031947532846002225 10031947532846002225 Yes Professor of Infectious Diseases, Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, IR Iran. Tel: +98-9151613942, Email: dr.m.ziaee@gmail.com Reza Dastjerdi 10031947532846002226 10031947532846002226 No Assistant Professor of Psychology, Birjand University of Medical Sciences, Birjand, Iran