en General پژوهشي Research Article Background and Objectives: Rabies is among the oldest known zoonoses. It has a high mortality rate, particularly in developing countries and in rural areas. Rabies prevention and management necessitates adequate information about public rabies-related knowledge and behavior. The present study was done to assess rabies-related knowledge, attitudes, and practice among nomads in South Khorasan province, Iran. Methods: This cross-sectional descriptive study was conducted in 2015 on 318 nomads. Sampling was done through multi-stage sampling. A researcher-made 36-item instrument was used for data collection. The data were entered in the SPSS software (v. 16) and analyzed through the Mann-Whitney U, Kruskal-Wallis test, and Spearman correlation analysis, at a significance level of less than 0.05. Results: A large number of participants had limited knowledge (139 cases; 43.4%), negative attitudes (139 cases; 42.9%), and moderate-level practice (183 cases; 57.5%) regarding rabies. There were significant positive correlations between knowledge and attitudes (r = 0.58; P < 0.001), knowledge and practice (r = 0.58; P < 0.001), and attitudes and practice (r = 0.56; P < 0.001). Moreover, rabies-related knowledge, attitudes, and practice had a significant relationship with age and educational status (P < 0.05). Conclusions: This study showed that most nomads in South Khorasan had poor rabies-related knowledge, attitudes, and practice. Therefore, educational strategies are needed to improve their rabies-related knowledge, attitude, and practice, in order to prevent rabies. Rabies,Knowledge,Attitude,Practice,Nomads 0 0 http://mcj.bums.ac.ir/browse.php?a_code=A-10-1-83&slc_lang=en&sid=1 Zahra Unesi 10031947532846003430 10031947532846003430 No Faculty of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, IR Iran Samaneh Nakhaee 10031947532846003431 10031947532846003431 Yes Samaneh Nakhaee, Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Moallem Avenue, Birjand, IR Iran. Tel/Fax: +98-5632381250, E-mail: nakhaee38@yahoo.com Zahra Amouzeshi 10031947532846003432 10031947532846003432 No Faculty of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, IR Iran Mohammadreza Jamavar 10031947532846003433 10031947532846003433 No Birjand University of Medical Sciences, South Khorasan Province Health Center, Birjand, IR Ira